Christopher Messina (born August 11, 1974) is an American actor, director, writer, and producer. He is best known for starring as Danny Castellano in the series The Mindy Project (2012–2017), which earned him two nominations for the Critics’ Choice Television Award for Best Actor in a Comedy Series.

He has appeared in films such as Vicky Cristina Barcelona (2008), Julie & Julia (2009), Devil (2010), Argo (2012), Ruby Sparks (2012), Celeste and Jesse Forever (2012), Cake (2014), Birds of Prey (2020), I Care a Lot (2020), Call Jane (2022), Air (2023) and The Boogeyman (2023). Messina wrote, executive produced, and starred in the comedy film Fairhaven (2012). He also directed and starred in the drama film Alex of Venice (2014).

On television, Messina appeared as Ted Fairwell in the HBO drama series Six Feet Under (2005), Chris Sanchez in the Audience Network legal thriller series Damages (2011–2012), Reese Lansing in the HBO political drama series The Newsroom (2012–2014), Richard Willis in the HBO miniseries Sharp Objects (2018), Nick Haas in the USA Network crime drama series The Sinner (2020), Angelo Lano in the Starz political miniseries Gaslit (2022), and as Nathan Bartlett in the Peacock comedy thriller Based on a True Story (2023).